Can Rexulti Help with Depression That Hasn't Responded to Treatment?

 

If you're dealing with major depression and standard treatments haven’t worked, your doctor may recommend adding Rexulti (brexpiprazole) to your current antidepressant. It’s designed to support emotional stability and improve mood in adults with treatment-resistant depression.

What Is Rexulti?
Rexulti belongs to a class of medications known as atypical antipsychotics. While originally used for conditions like schizophrenia, it is also prescribed to help people with MDD who haven’t responded well to traditional antidepressants alone.

How It Works
Rexulti acts on dopamine and serotonin systems in the brain—key players in emotional regulation. Its goal is to improve:

Sad or hopeless feelings

Low motivation

Trouble focusing

Emotional extremes

By targeting multiple pathways, it may offer relief where single-action antidepressants fall short.

Potential Side Effects
Everyone reacts differently, but common side effects may include:

Fatigue

Weight gain

Restlessness

Lightheadedness

Speak with your doctor about any new or unusual symptoms, especially during the early stages of treatment.

When to Expect Results
Most people begin noticing improvements within a few weeks, though some may take longer. Close communication with your healthcare provider is key during this time.

What If You Need to Stop?
Always speak with your doctor before stopping this medication. Tapering gradually helps avoid withdrawal symptoms or a sudden return of depression.

Important Notice: BYR is a Canadian & U.S. prescription referral service with a licensed contracted pharmacy department. We do not provide telehealth services and do not accept insurance. All prescriptions must be in English and written by a licensed U.S. medical doctor. We only fulfill prescriptions for personal use and ship directly to residential addresses in the U.S. Please allow 7–10 business days from the time of shipment for your medication to arrive.


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